Evaluation of renal toxicity by combination exposure to melamine and cyanuric acid in male Sprague-Dawley rats

Title
Evaluation of renal toxicity by combination exposure to melamine and cyanuric acid in male Sprague-Dawley rats
Author(s)
정태천손지연[손지연]강윤종[강윤종]김경석[김경석]김태형[김태형]임성광[임성광]임현중[임현중]최달웅[최달웅]정규혁[정규혁]이병무[이병무]김형식[김형식]
Keywords
Rattus
Issue Date
201406
Citation
Toxicological Research, v.30, no.2, pp.99 - 107
Abstract
Melamine-induced nephrotoxicity is closely associated with crystal formation in the kidney caused by combined exposure to melamine (Mel) and cyanuric acid (CA). However, there are few dosage-finding studies for toxicological evaluation of chronic co-exposure to Mel and CA. The objective of this study was to investigate the possible mechanism by which a Mel and CA mixture lead to renal toxicity in rats. Mel and CA were co-administered to rats via oral gavage for 50 days. Nephrotoxicity was determined by measuring blood urea nitrogen (BUN) and serum creatinine (sCr) levels. Relative kidney weights were significantly increased in rats after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg) mixtures. BUN and sCr levels were significantly increased after Mel and CA co-exposure. Taken together, significant increase in KIM-1, NGAL, and calbindin levels were observed in the urine of rats exposed to Mel+CA (63/6.3 or 630/6.3 mg/kg) compared with the corresponding control group. Histological analysis revealed epithelial degeneration and necrotic cell death in the proximal tubules of the kidney after co-exposure to Mel+CA (63/6.3 or 630/6.3 mg/kg). Our data suggest that Mel-mediated renal toxicity may be influenced by CA concentrations in Mel-contaminated milk or foods. ? 2014 The Korean Society of Toxicology.
URI
http://hdl.handle.net/YU.REPOSITORY/31864http://dx.doi.org/10.5487/TR.2014.30.2.099
ISSN
1976-8257
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약학대학 > 약학부 > Articles
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