Postoperative Complications after Preoperative Chemoradiotherapy Combined with Hyperthermia in Locally Advanced Rectal Cancer

Title
Postoperative Complications after Preoperative Chemoradiotherapy Combined with Hyperthermia in Locally Advanced Rectal Cancer
Author(s)
예지원
Keywords
Rectal Cancer; Preoperative; Chemoradiotherapy; Hyperthermia; Complication
Issue Date
201406
Publisher
한국의학물리학회
Citation
의학물리, v.25, no.2, pp.89 - 94
Abstract
We investigated whether regional hyperthermia (HT) increased post-surgical complications in patients with locallyadvanced rectal cancer treated with preoperative concurrent chemoradiotherapy (CCRT). Between 1996 and2007, 205 patients treated with preoperative CCRT and curative surgery were evaluable for the analysis of acuteand late toxicities. A total dose of 39.6 Gy or 45 Gy was delivered concurrently with one or two cycles ofchemotherapy (5-fluorouracil, leucovorin). Eighty-eight patients received regional HT twice a week using an8-MHz radiofrequency capacitive heating device. Surgery was performed 4∼6 weeks after the completion ofpreoperative CCRT. The median age was 59 years (range, 18∼83) and the median follow-up period was61months (range, 2∼191). The 5-year overall survival and complication-free survival rate of all patients was77.4% and 73.7%, respectively. Early leakage, delayed leakage, anastomotic stricture, fistula, and small bowelobstruction occurred in 1.0%, 2.9%, 1.5%, 5.9%, and 17.1%, respectively. HT did not increase all kinds ofcomplications. The 5-year complication-free survival rate was 71.8% in the non-HT group and 76.3% in theHT group (p=0.293). Regional HT did not increase postoperative complications in patients with locally advancedrectal cancer treated with preoperative CCRT followed by curative surgery.
URI
http://hdl.handle.net/YU.REPOSITORY/31784http://dx.doi.org/10.14316/pmp.2014.25.2.89
ISSN
1226-5829
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의과대학 > 방사선종양학교실 > Articles
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