Antiviral mode of action of Lactobacillus plantarum YML009 on Influenza virus H1N1

Title
Antiviral mode of action of Lactobacillus plantarum YML009 on Influenza virus H1N1
Author(s)
최광호[최광호]비벡바지파이박용하라더이르판아흐마드
Keywords
LACTIC-ACID BACTERIA; AVIAN INFLUENZA; INFECTION; HEALTH; MILK; MICE
Issue Date
201506
Publisher
BANGLADESH PHARMACOLOGICAL SOC
Citation
BANGLADESH JOURNAL OF PHARMACOLOGY, v.10, no.2, pp.475 - 482
Abstract
The development of resistance against antiviral agents has augmented a threat to public health sector. Consequently there is an expanding demand for the development of unconventional antiviral agents that could efficiently replace the existent in-use drugs. The probiotic strains of lactic acid bacteria (LAB) have earned the status of being efficient, economical and safe "nutraceutical" in health care armamentarium. A total of 2272 LAB strains were screened against H1N1 virus. The isolate YML009 displayed a pronounced antiviral activity. Sequencing and biochemical assays identified the isolate as Lactoballius plantarum which, exhibited resistance to the damage caused by the acidic conditions such as gastric juice and 5% bile salt. The anti-H1N1 activity of the strain was confirmed by hemagglutination assay and was found to display enhanced efficacy in comparison to the commercially available antiviral drug. This is a primary report on anti-influenza activity of a bacterium L. plantarum YML009.
URI
http://hdl.handle.net/YU.REPOSITORY/31712http://dx.doi.org/10.3329/bjp.v10i2.23068
ISSN
1991-007X
Appears in Collections:
중앙도서관 > rims journal
생명공학부 > 생명공학부 > Articles
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