국내 노인 심부전 환자에서의 잠재적으로 부적절한 약물사용 현황에 대한 연구

Title
국내 노인 심부전 환자에서의 잠재적으로 부적절한 약물사용 현황에 대한 연구
Other Titles
Assessment of Potentially Inappropriate Medication Use in Korean Elderly Patients with Chronic Heart Failure
Author(s)
이인향배민경[배민경]윤정현[윤정현]
Keywords
Elderly patients; Beers criteria; PIM; Inappropriate Medication Use; CHF
Issue Date
201406
Publisher
한국임상약학회
Citation
한국임상약학회지, v.24, no.2, pp.115 - 125
Abstract
Purpose: The purpose of the present study was to assess the incidence of the potentially inappropriate medication (PIM)use in Korean elderly patients with heart failure, and to evaluate factors that influence PIM use. Method: Korean NationalHealth Insurance claims database between January 2009 and December 2009 was used. Using 2012 updated Beers criteria,PIM use in heart failure patients aged 65 years or older was examined. Result: The incidence of PIM use in elderlyheart failure patients was higher than in overall elderly patients. Among the 12,759 elderly patients with heart failure,46.2% of study subjects were prescribed PIM(s) at least once. The number of PIM per 10 medications that patientsreceived per patient was 1.53. The most commonly used PIMs in elderly heart failure patients were benzodiazepines(30.9%), non-steroidal anti-inflammatory drugs (NSAIDs) including COX-2 inhibitors (16.3%), digoxin (9.9%), andspironolactone (9.0%). Women (odds ratio, 1.20; 95% CI, 1.17-1.24), medical aid (odds ratio, 1.11; 95% CI, 1.08-1.13),and long-term facilities (odds ratio, 2.69; 95% CI, 2.44-2.96) were revealed to be important factors associated with PIMuse. In addition, patient’s age also seems to influence PIM use. Conclusion: Elderly heart failure patients are at agreater risk for adverse drug events attributed by inappropriate medication use. Efforts to increase awareness of PIMuse in elderly heart failure patients are needed. In addition, various comprehensive strategies and policies to identifyand prevent PIM use should be established nationwide.
URI
http://hdl.handle.net/YU.REPOSITORY/31681
ISSN
1226-6051
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약학대학 > 약학부 > Articles
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