The Pharmacological Effects of Benachio-F (R) on Rat Gastrointestinal Functions

Title
The Pharmacological Effects of Benachio-F (R) on Rat Gastrointestinal Functions
Author(s)
김종오포우델비자이유재영[유재영]권용삼[권용삼]박형근[박형근]손미원[손미원]전준호[전준호]김정아[김정아]
Keywords
QUALITY-OF-LIFE; POSTOPERATIVE ILEUS; STW-5 IBEROGAST(R); RECEPTOR ANTAGONIST; HERBAL PREPARATION; DYSPEPSIA; MOTILITY; COMPONENTS; DISORDERS; POPULATION
Issue Date
201507
Publisher
KOREAN SOC APPLIED PHARMACOLOGY
Citation
BIOMOLECULES & THERAPEUTICS, v.23, no.4, pp.350 - 356
Abstract
Functional dyspepsia (FD) is a prevalent idiopathic upper gastrointestinal (GI) disorder characterized by diverse symptomatology including epigastric pain or discomfort, postprandial fullness, and early satiety. Although its pathophysiological mechanisms have not yet been fully established, the available studies suggest that the etiology of FD is invariably multifactorial. Benachio-F (R) (BF) is a proprietary liquid formulation of 7 herbal extracts that has been proposed to address this multifactorial etiology using multi-drug phytotherapy. The pharmacological effects of BF, in comparison with those of two other herbal products (Whalmyungsu (R); WM and Iberogast (R); IB) were evaluated in rats. In a laparotomy-induced rat model of delayed GI transit, BE significantly accelerated the delayed gastric emptying caused by morphine, apomorphine, and cisplatin, and also significantly increased mean gastric transit, as compared to the control animals. BF markedly increased gastric accommodation in rats and produced higher gastric volume values than did the control treatment. The effects of BE were generally comparable or superior to those of WM and IB in these models. Furthermore, BE significantly stimulated biliary flow, as compared to the control treatment. These results indicated that BE might have great potential as an effective phytotherapeutic agent capable of reducing GI symptoms and increasing quality of life in FD patients.
URI
http://hdl.handle.net/YU.REPOSITORY/31671http://dx.doi.org/10.4062/biomolther.2015.035
ISSN
1976-9148
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약학대학 > 약학부 > Articles
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