Modulation of Cell Death and Survival by Adipokines in the Liver

Title
Modulation of Cell Death and Survival by Adipokines in the Liver
Author(s)
박필훈사로즈네팔
Keywords
HEME OXYGENASE-1 INDUCTION; ETHANOL-INDUCED APOPTOSIS; HEPG2 CELLS; FATTY LIVER; ONCOGENIC ACTIONS; HEPATIC-FIBROSIS; STELLATE-CELLS; KUPFFER CELLS; CANCER-CELLS; IN-VITRO
Issue Date
201507
Publisher
PHARMACEUTICAL SOC JAPAN
Citation
BIOLOGICAL & PHARMACEUTICAL BULLETIN, v.38, no.7, pp.961 - 965
Abstract
Adipokines, hormones predominantly produced from adipose tissue, have been shown to impart dynamic functions in the liver. Emerging evidence has shown that adipokines are also involved in modulating liver cell survival and/or death. Among the various adipokines, adiponectin and leptin directly regulate proliferation of hepatocytes, Kupffer cells, and hepatic stellate cells. Moreover, these adipokines control apoptosis and cell cycle of hepatic cancer cells in a complex manner. Adiponectin possesses both pro- and anti-proliferative properties, whereas leptin appears to play roles as a pro-survival hormone. Recent studies have revealed that regulation of cell death and proliferation is one of the critical factors regulating liver physiology by adipokines. In this review, we summarize the effects of adipokines on apoptosis and survival of liver cells and also demonstrate their implications in regulating various liver functions and decipher the underlying molecular mechanisms.
URI
http://hdl.handle.net/YU.REPOSITORY/31669
ISSN
0918-6158
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약학대학 > 약학부 > Articles
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