Development of a novel triamcinolone acetonide-loaded spray solution for the treatment of stomatitis

Title
Development of a novel triamcinolone acetonide-loaded spray solution for the treatment of stomatitis
Author(s)
용철순김동육[김동육]김용일한홍희Fakhar ud Din[Fakhar ud Din]조관형[조관형]김종오최한곤[최한곤]
Keywords
BUCCAL ADHESIVE TABLETS; IN-VIVO EVALUATION; PHYSICOCHEMICAL CHARACTERIZATION; INFLAMMATORY CYTOKINES; LIQUID SUPPOSITORY; BEAGLE DOGS; OMEPRAZOLE; RELEASE; PHONOPHORESIS; MUCOADHESIVE
Issue Date
201407
Publisher
GOVI-VERLAG PHARMAZEUTISCHER VERLAG GMBH
Citation
PHARMAZIE, v.69, no.7, pp.512 - 517
Abstract
To develop a novel triamcinolone acetonide (TAA)-loaded spray for the treatment of stomatitis, several spray solutions were prepared using various amounts of TAA, Eudragit (R) L100 (Eudragit L) and PEG 400, and 100 ml ethanol. Their viscosity and spraying potential were investigated, with the result that the spraying threshold was 9.5 cP. The effect of PEG 400 on the properties of films formed after spraying was assessed. Its anti-inflammatory effect in mice was evaluated and compared to a commercial product. As the PEG 400 concentration increased, the film elongation and washability by the saliva solution increased, and tensile strength decreased. PEG 400 had little effect on mucoadhesive force and drug release. The TAA-loaded spray solution containing TAA, Eudragit L, PEG 400 and ethanol at the ratio of 1:6:3:100 (w/w/w/v) was easy to spray onto stomatitis lesions in the mouth via a spraying vessel incorporating a long straw. After spraying, the TAA-loaded spray formed a film with suitable elongation, tensile strength and washability that attached onto the nnucosal membrane and released the drug. Moreover, it had excellent anti-inflammatory properties, similar to those of the commercial product. Thus, this novel TAA-loaded spray solution was easy to administer, had good film properties and excellent anti-inflammatory efficacy, and is therefore a potential candidate for the treatment of stomatitis.
URI
http://hdl.handle.net/YU.REPOSITORY/31577http://dx.doi.org/10.1691/ph.2014.3235
ISSN
0031-7144
Appears in Collections:
약학대학 > 약학부 > Articles
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