Sterols from Hericium erinaceum and their inhibition of TNF-alpha and NO production in lipopolysaccharide-induced RAW 264.7 cells

Title
Sterols from Hericium erinaceum and their inhibition of TNF-alpha and NO production in lipopolysaccharide-induced RAW 264.7 cells
Author(s)
이위Zhou Wei[Zhou Wei]차지윤[차지윤]권세욱[권세욱]백광현심상희[심상희]이영미[이영미]김영호[김영호]
Keywords
GROWTH-FACTOR (NGF)-SYNTHESIS; SPONGIA-OFFICINALIS; CORDYCEPS-SINENSIS; AROMATIC-COMPOUNDS; MUSHROOM; MYCELIA; STIMULATORS; CONSTITUENTS; DITERPENOIDS
Issue Date
201507
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
PHYTOCHEMISTRY, v.115, pp.231 - 238
Abstract
Erinarols G-J and 10 known ergostane-type sterols were isolated from a methanol extract of the dried fruiting bodies of Hericium erinaceum. Their chemical structures were elucidated using extensive spectroscopic analyses including 1D and 2D NMR experiments and HR-ESI-MS analysis, as well as through comparison with previously reported data. Anti-inflammatory effects of the isolated compounds were evaluated in terms of inhibition of tumor necrosis factor alpha (TNF-alpha) and nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophage cells. The results showed that erinarols H and J, as well as 2 of the ergostane-type sterols exhibited inhibitory activity against TNF-alpha secretion, with inhibition values ranging from 33.7% to 43.3% at 10 mu M. Erinarols J and three ergostane-type sterols exhibited significant inhibitory effects against NO production, with inhibition values ranging from 38.4% to 71.5% at 10 mu M. (C) 2015 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/31575http://dx.doi.org/10.1016/j.phytochem.2015.02.021
ISSN
0031-9422
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생명공학부 > 생명공학부 > Articles
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