In vivo anti-inflammatory, analgesic and antipyretic activities of a medicinal plant, Caesalpinia bonducella F.

Title
In vivo anti-inflammatory, analgesic and antipyretic activities of a medicinal plant, Caesalpinia bonducella F.
Author(s)
슈리티슈클라Archana Mehta[Archana Mehta]
Keywords
EXTRACT
Issue Date
201507
Publisher
UNIV KARACHI
Citation
PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, v.28, no.4, pp.1517 - 1521
Abstract
This research examined antipyretic, anti-inflammatory, and analgesic activities of ethanolic extract of C. bonducella whole seeds in experimental albino rats. Three doses, 100, 200 and 400 mg/kg of the whole seed ethanolic extract prepared as a suspension in 2 ml of 2% gum acacia were used. Acute inflammatory and antipyretic activities were evaluated in experimental animals by carrageenan induced paw edema and brewer's yeast-induced pyrexia models, respectively. A significant (p<0.05) reduction in paw volumes, and pyrexia was noted in experimental animals when compared with control animals. The ethanol see extract (400 mg/kg) displayed in vivo anti-inflammatory, antipyretic and analgesic in terms of reduction in paw edema, % writhes inhibition and rectal temperature by (0.24 +/- 0.03), (31.38%) and (36.2 +/- 0.1), respectively. Overall the whole ethanolic seed extract at all tested concentrations produced significant (p<0.05) anti-inflammatory, antipyretic and analgesic activities. The results obtained in this study clearly indicated the ethno-medicinal potential of C. bonducella in curing pain and inflammation related disorders, supporting its efficacy as a natural analgesic, antipyretic and anti-inflammatory agent.
URI
http://hdl.handle.net/YU.REPOSITORY/31539
ISSN
1011-601X
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중앙도서관 > rims journal
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