Reducing the cytotoxicity of inhalable engineered nanoparticles via in situ passivation with biocompatible materials

Title
Reducing the cytotoxicity of inhalable engineered nanoparticles via in situ passivation with biocompatible materials
Author(s)
변정훈박재홍[박재홍]Thomas M. Peters[Thomas M. Peters]Jeffrey T. Roberts[Jeffrey T. Roberts]
Keywords
AEROSOL-BASED FABRICATION; WELDING FUMES; WORKPLACE EXPOSURE; IRON-OXIDE; CHITOSAN; SYSTEM; STEEL; NANOCOMPOSITES; INHALATION; STAINLESS
Issue Date
201507
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF HAZARDOUS MATERIALS, v.292, pp.118 - 125
Abstract
The cytotoxicity of model welding nanoparticles was modulated through in situ passivation with soluble biocompatible materials. A passivation process consisting of a spark discharge particle generator coupled to a collison atomizer as a co-flow or counter-flow configuration was used to incorporate the model nanoparticles with chitosan. The tested model welding nanoparticles are inhaled and that A549 cells are a human lung epithelial cell line. Measurements of in vitro cytotoxicity in A549 cells revealed that the passivated nanoparticles had a lower cytotoxicity (>65% in average cell viability, counter-flow) than the untreated model nanoparticles. Moreover, the co-flow incorporation between the nanoparticles and chitosan induced passivation of the nanoparticles, and the average cell viability increased by >80% compared to the model welding nanoparticles. As a more convenient way (additional chitosan generation and incorporation devices may not be required), other passivation strategies through a modification of the welding rod with chitosan adhesive and graphite paste did also enhance average cell viability (>58%). The approach outlined in this work is potentially generalizable as a new platform, using only biocompatible materials in situ, to treat nanoparticles before they are inhaled. (C) 2015 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/31533http://dx.doi.org/10.1016/j.jhazmat.2015.03.022
ISSN
0304-3894
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공과대학 > 기계공학부 > Articles
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