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dc.contributor.author김재룡ko
dc.contributor.author양효현[양효현]ko
dc.contributor.author황보경ko
dc.contributor.authorZheng Ming Shan[Zheng Ming Shan]ko
dc.contributor.author손종근ko
dc.contributor.author김화영ko
dc.contributor.author백석환ko
dc.contributor.author최형철ko
dc.contributor.author박소영ko
dc.date.accessioned2015-12-17T04:09:31Z-
dc.date.available2015-12-17T04:09:31Z-
dc.date.created2015-11-13-
dc.date.issued201407-
dc.identifier.citationJOURNAL OF NATURAL MEDICINES, v.68, no.3, pp.473 - 480-
dc.identifier.issn1340-3443-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/31519-
dc.identifier.urihttp://dx.doi.org/10.1007/s11418-014-0817-0-
dc.description.abstractCellular senescence contributes to tissue and organismal aging, tumor suppression and progress, tissue repair and regeneration, and age-related diseases. Thus, aging intervention might be a promising target for treatment and prevention of diverse age-related diseases. In the present study, we investigated whether juglanin purified from the crude extract of Polygonum aviculare exerted inhibitory activity against cellular senescence in human dermal fibroblasts (HDFs). Juglanin decreased senescence-associated beta-galactosidase activity (SA-beta-gal) and the level of reactive oxygen species in senescent cells induced by adriamycin treatment. Juglanin also repressed SA-beta-gal activity in HDFs under replicative senescence. These results suggest that juglanin represses cellular senescence in HDFs and might be useful for the development of dietary supplements or cosmetics that alleviate tissue aging or age-related diseases.-
dc.language영어-
dc.publisherSPRINGER JAPAN KK-
dc.subjectLIFE-SPAN-
dc.subjectCELLS-
dc.subjectINDUCTION-
dc.titleInhibitory effects of juglanin on cellular senescence in human dermal fibroblasts-
dc.typeArticle-
dc.identifier.wosid000337168300002-
dc.identifier.scopusid2-s2.0-84904706738-
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의과대학 > 생화학.분자생물학교실 > Articles
약학대학 > 약학부 > Articles
의과대학 > 약리학교실 > Articles
의과대학 > 생리학교실 > Articles
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