Inhibitory effects of juglanin on cellular senescence in human dermal fibroblasts

Title
Inhibitory effects of juglanin on cellular senescence in human dermal fibroblasts
Author(s)
김재룡양효현[양효현]황보경Zheng Ming Shan[Zheng Ming Shan]손종근김화영백석환최형철박소영
Keywords
LIFE-SPAN; CELLS; INDUCTION
Issue Date
201407
Publisher
SPRINGER JAPAN KK
Citation
JOURNAL OF NATURAL MEDICINES, v.68, no.3, pp.473 - 480
Abstract
Cellular senescence contributes to tissue and organismal aging, tumor suppression and progress, tissue repair and regeneration, and age-related diseases. Thus, aging intervention might be a promising target for treatment and prevention of diverse age-related diseases. In the present study, we investigated whether juglanin purified from the crude extract of Polygonum aviculare exerted inhibitory activity against cellular senescence in human dermal fibroblasts (HDFs). Juglanin decreased senescence-associated beta-galactosidase activity (SA-beta-gal) and the level of reactive oxygen species in senescent cells induced by adriamycin treatment. Juglanin also repressed SA-beta-gal activity in HDFs under replicative senescence. These results suggest that juglanin represses cellular senescence in HDFs and might be useful for the development of dietary supplements or cosmetics that alleviate tissue aging or age-related diseases.
URI
http://hdl.handle.net/YU.REPOSITORY/31519http://dx.doi.org/10.1007/s11418-014-0817-0
ISSN
1340-3443
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
약학대학 > 약학부 > Articles
의과대학 > 약리학교실 > Articles
의과대학 > 생리학교실 > Articles
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