Injury of the mammillothalamic tract in patients with subarachnoid haemorrhage: a retrospective diffusion tensor imaging study

Title
Injury of the mammillothalamic tract in patients with subarachnoid haemorrhage: a retrospective diffusion tensor imaging study
Author(s)
장성호최병연김성호장철훈정영진권혁규
Keywords
MINI-MENTAL STATE; CORTICOSPINAL TRACT; COGNITIVE DYSFUNCTION; HUMAN BRAIN; TRACTOGRAPHY; IMPAIRMENT; PREDICTORS; MEMORY; CONNECTIONS; RECOVERY
Issue Date
201407
Publisher
BMJ PUBLISHING GROUP
Citation
BMJ OPEN, v.4, no.7
Abstract
Objective: Few studies have reported on injury of the mammillothalamic tract (MTT) in patients with stroke. However, no study in patients with subarachnoid haemorrhage (SAH) has been reported. Using diffusion tensor tractography, we attempted to investigate injury of the MTT in patients with SAH. Methods: We recruited 16 patients with SAH and 15 control participants. DTI was obtained at 5.7+/-1.5 weeks after onset and reconstruction of the MTT was performed using the probabilistic tractography method. The fractional anisotropy (FA) value and tract number of the MTT and the Mini-Mental State Examination (MMSE) score were determined. Values of FA and tract volume showing a decrement of more than two SDs that of normal control were defined as abnormal. Results: The FA value and tract volume in the patient group were significantly lower than those in the control group (p<0.05). In addition, MMSE showed strong (r=0.67, p=0.005) positive correlation with tract volume without correlation with FA. In the individual analysis, 16 MTTs of 32 MTTs in 16 patients showed abnormalities of the MTT in terms of the FA value, the tract volume or the presence of a reconstructed MTT. As a result, 10 (62.5%) of 16 patients showed abnormality of the MTT in at least one hemisphere. Conclusions: We found that patients with SAH showed injury of the MTT and this injury showed correlation with cognitive dysfunction.
URI
http://hdl.handle.net/YU.REPOSITORY/31510http://dx.doi.org/10.1136/bmjopen-2014-005613
ISSN
2044-6055
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의과대학 > 재활의학교실 > Articles
의과대학 > 신경외과학교실 > Articles
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