Synthesis of 6-deoxymollugins and their inhibitory activities on tyrosinase

Title
Synthesis of 6-deoxymollugins and their inhibitory activities on tyrosinase
Author(s)
장영동량경록우마이르자베드이승호박재규[박재규]
Keywords
GALIUM-MOLLUGO L; MELANOGENESIS INHIBITOR; MUSHROOM TYROSINASE; STOBBE CONDENSATION; RUBIA-CORDIFOLIA; MELANOMA-CELLS; ACID; ANTHRAQUINONES; BIOSYNTHESIS; MECHANISM
Issue Date
201407
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.37, no.7, pp.862 - 872
Abstract
A series of 6-deoxymollugins were prepared five steps from benzaldehyde and its derivatives via phenylboronic acid-catalyzed chromenylation as a key step. Their inhibitory activities against tyrosinase from mushroom were evaluated to show that the parent, methyl 2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate (9a) showed best and promising inhibitory activity at IC50 = 18.3 mu M.
URI
http://hdl.handle.net/YU.REPOSITORY/31503http://dx.doi.org/10.1007/s12272-013-0240-1
ISSN
0253-6269
Appears in Collections:
약학대학 > 약학부 > Articles
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