Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients

Title
Paradoxical Increase of IgE Binding Components during Allergen-Specific Immunotherapy in Pollinosis Patients
Author(s)
진현정김미애[김미애]윤문경[윤문경]신유섭[신유섭]박해심[박해심]
Keywords
CLIMATE-CHANGE; RHINITIS; KOREA; DIAGNOSIS; DISEASES; PATTERNS; IMPACT
Issue Date
201407
Publisher
KOREAN ACAD MEDICAL SCIENCES
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.29, no.7, pp.1025 - 1029
Abstract
Allergen-specific immunotherapy (SIT) reduces allergen specific IgE (sIgE) levels and achieves clinical and immunological tolerance by modulating innate and adaptive immunological responses. Increased temperature and CO2 concentrations caused by climate changes contribute to an increase of pollen count and allergenicity that influences clinical SIT outcomes. In this study, we investigated the changes of IgE binding components to tree and weed pollens in pollinosis patients who showed a paradoxical increase of serum sIgE level during pollen-SIT. We enrolled nine patients who showed an increasing pattern of serum sIgE level to alder, birch, ragweed and mugwort pollens by enzyme-linked immunosorbant assay. IgE immunoblot analysis confirmed the intensification or new generation of major IgE binding components that could be induced by climate change. The findings suggest that the regular monitoring of sIgE levels and symptom changes is required to improve the clinical outcomes of SIT in patients undergoing SIT for tree and weed pollens.
URI
http://hdl.handle.net/YU.REPOSITORY/31470http://dx.doi.org/10.3346/jkms.2014.29.7.1025
ISSN
1011-8934
Appears in Collections:
의과대학 > 내과학교실 > Articles
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