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dc.contributor.author정태천ko
dc.contributor.author최재호[최재호]ko
dc.contributor.author진순우[진순우]ko
dc.contributor.author한은희[한은희]ko
dc.contributor.author박봉환[박봉환]ko
dc.contributor.author김형균[김형균]ko
dc.contributor.authorT Khanal[T Khanal]ko
dc.contributor.author황용필[황용필]ko
dc.contributor.authorMT Do[MT Do]ko
dc.contributor.author이현선[이현선]ko
dc.contributor.author정영철[정영철]ko
dc.contributor.author김희석[김희석]ko
dc.contributor.author정혜광[정혜광]ko
dc.date.accessioned2015-12-17T04:08:48Z-
dc.date.available2015-12-17T04:08:48Z-
dc.date.created2015-11-13-
dc.date.issued201407-
dc.identifier.citationPHYTOMEDICINE, v.21, no.8-9, pp.1053 - 1061-
dc.identifier.issn0944-7113-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/31466-
dc.identifier.urihttp://dx.doi.org/10.1016/j.phymed.2014.04.011-
dc.description.abstractPurpose: The consequences of precipitously rising allergic skin inflammation rates worldwide have accelerated the risk of atopic dermatitis (AD). Natural product-based agents with good efficacy and low risk of side effects offer promising prevention and treatment strategies for inflammation-related diseases. We have already reported that Platycodon grandiflorum root-derived saponins (Changkil saponins, CKS) have many pharmacological effects, including anti-inflammatory and anti-allergic effects, but its influence on AD remains unclear. Therefore, we evaluated the inhibitory effect of CKS, mainly platycodin D, on AD-like skin symptoms in mice and the possible mechanisms in cells. Methods: Mice were sensitized and challenged with 2,4-dinitrochlorobenzene (DNCB). Four weeks after challenge, mice were treated with oral administration of CKS for 4 weeks. In addition, cells were used to evaluate the effect of CKS, mainly platycodin D, on the TARC expression regulated mechanism. Results: CKS attenuated DNCB-induced dermatitis severity, serum levels of IgE and TARC, and mRNA expression of TARC, TNF-alpha, IFN-gamma, IL-4, IL-5, and IL-13 in mice. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells and mast cells in the ears. Moreover, CKS and platycodin D inhibited TNF-alpha/IFN-gamma-induced TARC expression through the suppression of NF-kappa B and STAT1 and induction of Nrf2/ARE-mediated hemeoxygenase-1 (HO-1) expression in cells. Conclusion: We suggest that CKS and platycodin D inhibited the development of AD-like skin symptoms by regulating cytokine mediators and may be an effective alternative therapy for AD-like skin symptoms. (C) 2014 Elsevier GmbH. All rights reserved.-
dc.language영어-
dc.publisherELSEVIER GMBH, URBAN & FISCHER VERLAG-
dc.subjectNC/NGA MICE-
dc.subjectCELLS-
dc.subjectRADIX-
dc.subjectRATS-
dc.subjectINFLAMMATION-
dc.subjectINHIBITION-
dc.subjectDISEASES-
dc.subjectSERUM-
dc.titlePlatycodon grandiflorum root-derived saponins attenuate atopic dermatitis-like skin lesions via suppression of NF-kappa B and STAT1 and activation of Nrf2/ARE-mediated heme oxygenase-1-
dc.typeArticle-
dc.identifier.wosid000337932000007-
dc.identifier.scopusid2-s2.0-84901984401-
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