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dc.contributor.author조경현ko
dc.contributor.author박기훈ko
dc.contributor.author김종민ko
dc.date.accessioned2015-12-17T04:08:40Z-
dc.date.available2015-12-17T04:08:40Z-
dc.date.created2015-11-13-
dc.date.issued201407-
dc.identifier.citationMOLECULAR NUTRITION & FOOD RESEARCH, v.58, no.7, pp.1537 - 1545-
dc.identifier.issn1613-4125-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/31456-
dc.identifier.urihttp://dx.doi.org/10.1002/mnfr.201300955-
dc.description.abstractScope: It is well known that trans-fatty acids have proatherogenic properties while HDL has antiatherogenic activities in plasma. However, there has been no report on the effects of trans-fat on the functional and structural properties of HDL. Methods and results: To compare physiological properties, we synthesized reconstituted HDL (rHDL) containing stearic acid (18:0), oleic acid (18:1, cis), or elaidic acid (EA, 18:1, trans). An rHDL containing EA (EA-rHDL) showed loss of antioxidant ability and induced the highest uptake of oxidized LDL into human macrophages. EA-rHDL caused the strongest cellular senescence in human dermal fibroblast cells along with the highest production of inflammatory species in macrophages co-treated with fructose. Injection of EA-rHDL into zebrafish embryos resulted in acute embryonic toxicity with the lowest survivability. Consumption of trans-fat for 20 weeks resulted in remarkable hyperlipidemia, elevation of serum cholesteryl ester transfer protein activity, hepatic inflammation, and fatty liver changes. Conclusion: Incorporation of EA impaired the beneficial effects of rHDL against atherogenesis. In zebrafish, EA-rHDL resulted in acute embryonic toxicity, and consumption of EA caused remarkable hyperlipidemia, inflammation, and fatty liver changes.-
dc.language영어-
dc.publisherWILEY-BLACKWELL-
dc.subjectAPOLIPOPROTEIN-A-I-
dc.subjectCHOLESTERYL ESTER TRANSFER-
dc.subjectTRANSFER PROTEIN-ACTIVITY-
dc.subjectHEART-DISEASE-
dc.subjectLIPID-FREE-
dc.subjectTRANS-
dc.subjectSENESCENCE-
dc.subjectHDL-
dc.subjectMETAANALYSIS-
dc.subjectMEMBRANE-
dc.titleElaidic acid (EA) generates dysfunctional high-density lipoproteins and consumption of EA exacerbates hyperlipidemia and fatty liver change in zebrafish-
dc.typeArticle-
dc.identifier.wosid000339001900015-
dc.identifier.scopusid2-s2.0-84903534961-
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