Novel Dual Drug-Loaded Block Ionomer Complex Micelles for Enhancing the Efficacy of Chemotherapy Treatments

Title
Novel Dual Drug-Loaded Block Ionomer Complex Micelles for Enhancing the Efficacy of Chemotherapy Treatments
Author(s)
김종오티르거네쉬라마사미김정환최한곤[최한곤]용철순
Keywords
MULTIDRUG-RESISTANCE; COMBINATION THERAPY; POLYMERIC MICELLES; CONTRAST AGENTS; ENDOSOMAL PH; DELIVERY; NANOPARTICLES; DOXORUBICIN; CANCER; CORE
Issue Date
201407
Publisher
AMER SCIENTIFIC PUBLISHERS
Citation
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v.10, no.7, pp.1304 - 1312
Abstract
Combination of two or more drugs has emerged as a promising strategy to elicit synergistic therapeutic responses that can overcome multidrug resistance of cancer cells at various stages of the growth cycle. In the current study, we investigated the efficacy of two drugs, mitoxantrone (MTX) and doxorubicin (DOX), co-encapsulated in a polyethylene oxide-b-polyacrylic acid polymer. The resulting block ionomer complex (BIC)-based combination chemotherapy provides a novel method for enhancing the therapeutic efficacy of chemotherapies. The BIC micelles were very stable at physiological pH, and showed a temporally sequenced release profile for the co-encapsulated drugs at tumor pH. This suggests that the micelles can deliver chemotherapeutic agents at the appropriate cellular stage. At a predetermined and carefully controlled ratio (MTX: DOX=2:1), the two drugs worked synergistically within A549 small lung cancer cells. Taken together, these findings suggest that the synergistic activity of ratiometrically controlled drug combinations can enhance their chemotherapeutic action and overall therapeutic index.
URI
http://hdl.handle.net/YU.REPOSITORY/31444http://dx.doi.org/10.1166/jbn.2014.1821
ISSN
1550-7033
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약학대학 > 약학부 > Articles
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