Influence of boost radiotherapy in patients with ductal carcinoma in situ breast cancer: a multicenter, retrospective study in Korea (KROG 11-04)

Title
Influence of boost radiotherapy in patients with ductal carcinoma in situ breast cancer: a multicenter, retrospective study in Korea (KROG 11-04)
Author(s)
예지원김진희[김진희]강민규최두호[최두호]박원[박원]안승도[안승도]김수산[김수산]하성환[하성환]김규보[김규보]신경환[신경환]김영배[김영배]서창옥[서창옥]김동원[김동원]
Keywords
LOCAL RECURRENCE; RADIATION-THERAPY; SECTOR RESECTION; HER2 STATUS; TUMOR BED; DCIS; OUTCOMES; WOMEN; TRIAL; TRASTUZUMAB
Issue Date
201407
Publisher
SPRINGER
Citation
BREAST CANCER RESEARCH AND TREATMENT, v.146, no.2, pp.341 - 345
Abstract
To estimate the effect of boost radiotherapy on local recurrence-free survival (LRFS) in patients with ductal carcinoma in situ (DCIS) breast cancer. We included patients from nine institutions who met the following criteria: having Tis, age 18 years or older, having breast conserving surgery (BCS) and radiotherapy within 12 weeks after surgery. From 1995 through 2006, 728 patients were analyzed retrospectively by the Korean Radiation Oncology Group. All patients received whole-breast radiation therapy (WBRT) after BCS. 232 patients (31.9 %) also received boost radiation therapy (RT) (median 10 Gy). After median follow-up of 82 months, 5-year LRFS was 98.4 % and 10-year LRFS was 95.8 % for all patients. There was no statistically significant difference of LRFS between the boost and no-boost groups. Nineteen (2.6 %) patients had ipsilateral breast recurrences, including 12 of invasive recurrence and 7 DCIS. The presence of the HER2 receptor was associated with more invasive recurrences. Nine (1.2 %) patients developed contralateral breast cancer, including six invasive breast cancer and three DCIS. In the multivariate analysis, only the margin status was a significant prognostic factor for LRFS. Boost RT was not associated with further improvement of local control in DCIS after BCS and WBRT. HER2 receptor-positive patients may need further treatment with the anti-HER2 agents.
URI
http://hdl.handle.net/YU.REPOSITORY/31427http://dx.doi.org/10.1007/s10549-014-3025-4
ISSN
0167-6806
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의과대학 > 방사선종양학교실 > Articles
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