Hericirine, a novel anti-inflammatory alkaloid from Hericium erinaceum

Title
Hericirine, a novel anti-inflammatory alkaloid from Hericium erinaceum
Author(s)
심상희이위Wei Zhou[Wei Zhou]이동성[이동성]김윤철[김윤철]김영호[김영호]
Keywords
AROMATIC-COMPOUNDS; MUSHROOM; MACROPHAGES
Issue Date
201407
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
TETRAHEDRON LETTERS, v.55, no.30, pp.4086 - 4090
Abstract
A novel ergosterol conjunction-type alkaloid, hericirine (1), was isolated from the dried fruiting bodies of Hericium erinaceum. The overall framework of 1 was isolated, and combined with hericerin and ergosterol. Its structure was elucidated based on spectroscopic analysis using 1D and 2D NMR, IR and HRESIMS techniques. We found that hericirine significantly inhibited protein expression of iNOS and COX-2 and reduced NO, PGE(2), TNE-alpha, IL-6 and IL-1 beta production in RAW264.7 cells exposed to LPS. (C) 2014 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/31421http://dx.doi.org/10.1016/j.tetlet.2014.05.117
ISSN
0040-4039
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생명공학부 > 생명공학부 > Articles
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