A diterpenoid sugiol from Metasequoia glyptostroboides with alpha-glucosidase and tyrosinase inhibitory potential

Title
A diterpenoid sugiol from Metasequoia glyptostroboides with alpha-glucosidase and tyrosinase inhibitory potential
Author(s)
비벡바지파이강선철[강선철]
Keywords
MIKI EX HU
Issue Date
201407
Publisher
BANGLADESH PHARMACOLOGICAL SOC
Citation
BANGLADESH JOURNAL OF PHARMACOLOGY, v.9, no.3, pp.312 - 316
Abstract
Nowadays use of plant derived natural compounds have become a topic of increasing interest in food and medicine industries due to their multitude of biological and therapeutic properties. In this study, a diterpenoid compound sugiol, isolated from Metasequoia glyptostroboides was evaluated for alpha-glucosidase and tyrosinase inhibitory efficacy in terms of its potent antidiabetic and anti-melanogenesis potential, respectively. As a result, sugiol at the concentration range of (100-10,000 mu g/mL) and (20-500 mu g/mL) showed potent efficacy on inhibiting alpha-glucosidase and tyrosinase enzymes in vitro ranging from 12.34-63.47% and 28.22-67.43%, respectively. These findings confirm the therapeutic potential of diterpenoid compound sugiol from M. glyptostroboides as a novel candidate for using in food and medicine industry which may have practical potential to cure skin and diabetes mellitus type-2 related disorders.
URI
http://hdl.handle.net/YU.REPOSITORY/31420http://dx.doi.org/10.3329/bjp.v9i3.19026
ISSN
1991-007X
Appears in Collections:
중앙도서관 > rims journal
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