Nitric oxide-releasing chitosan film for enhanced antibacterial and in vivo wound-healing efficacy

Title
Nitric oxide-releasing chitosan film for enhanced antibacterial and in vivo wound-healing efficacy
Author(s)
김종오노진기[노진기]라즈쿠마르타파Nurhasni Hasan[Nurhasni Hasan]최문정[최문정]김정환이준희[이준희]구세광[구세광]유진욱[유진욱]
Keywords
POLYVINYL-ALCOHOL; ANTIMICROBIAL ACTIVITY; GEL CHARACTERIZATION; S-NITROSOTHIOLS; DRUG-DELIVERY; NITROFURAZONE; DRESSINGS; SYSTEMS; ROLES
Issue Date
201508
Publisher
ELSEVIER SCIENCE BV
Citation
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, v.79, pp.217 - 225
Abstract
Nitric oxide (NO) is a promising therapeutic agent with antibacterial and wound-healing properties. However, the gaseous state and short half-life of NO necessitate a formulation that can control its storage and release. In this study, we developed NO-releasing films (CS/NO film) composed of chitosan (CS) and S-nitrosoglutathione (GSNO) as a NO donor. Thermal analysis demonstrated molecular dispersion of GSNO in the films. In vitro release study revealed that NO release from CS/NO films followed Korsmeyer-Peppas model with Fickian diffusion kinetics. Moreover, the CS/NO film showed a stronger antibacterial activity against Pseudomonas aeruginosa (Gram-negative) and Staphylococcus aureus (Gram-positive) than the CS film. Further, the CS/NO film accelerated wound healing and epithelialization in a rat model of full-thickness wounds as compared to the CS film. Histopathological studies revealed that CS/NO films favorably enhanced the re-epithelialization and reconstruction of wounded skin. Therefore, our results suggest that CS/NO films could be a suitable formulation for treating full-thickness wounds. (C) 2015 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/31348http://dx.doi.org/10.1016/j.ijbiomac.2015.04.073
ISSN
0141-8130
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약학대학 > 약학부 > Articles
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