Thieny/Furanyl-hydroxyphenylpropenones as Inhibitors of LPS-induced ROS and NO Production in RAW 264.7 Macrophages, and Their Structure-Activity Relationship Study

Title
Thieny/Furanyl-hydroxyphenylpropenones as Inhibitors of LPS-induced ROS and NO Production in RAW 264.7 Macrophages, and Their Structure-Activity Relationship Study
Author(s)
이응석타라만카다얏김미진남태규[남태규]박필훈
Keywords
NITRIC-OXIDE; SYNTHETIC CHALCONES; OXIDATIVE STRESS; TOPOISOMERASE-I; CELLS; 1-FURAN-2-YL-3-PYRIDIN-2-YL-PROPENONE; HYDROXYCHALCONES; CYTOTOXICITY; PYRIDINES; FLAVONES
Issue Date
201408
Publisher
KOREAN CHEMICAL SOC
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.35, no.8, pp.2481 - 2486
Abstract
Twelve thienyl/furanyl-hydroxyphenylpropenones were Systematically designed and synthesized, and evaluated for their inhibitory effect on LPS-induced ROS and NO production in RAW 264.7 macrophages. Compound 11 displayed the most significant inhibitory activity of LPS-induced ROS and NO production in RAW 264.7 macrophages. Structure-activity relationship study indicated that para-hydroxyphenyl moiety plays an important role for inhibitory activities on both LPS-induced ROS and NO production as well as 3-thienyl moiety on molecule.
URI
http://hdl.handle.net/YU.REPOSITORY/31272http://dx.doi.org/10.5012/bkcs.2014.35.8.2481
ISSN
0253-2964
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE