Sesquiterpenoids with PPAR delta agonistic effect from a Korean marine sponge Ircinia sp.

Title
Sesquiterpenoids with PPAR delta agonistic effect from a Korean marine sponge Ircinia sp.
Author(s)
최혁재한동엽[한동엽]진정욱[진정욱]김희영[김희영]양인호[양인호]원동환[원동환]Merrick Ekins[Merrick Ekins]남상집[남상집]강헌중[강헌중]
Keywords
PAPUA-NEW-GUINEA; GENUS IRCINIA; POTENT; METABOLISM; INHIBITORS
Issue Date
201408
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
TETRAHEDRON LETTERS, v.55, no.34, pp.4716 - 4719
Abstract
One monocyclofarnesol-derived sesquiterpenoid (1), four new meroterpenoids (2-5) as well as two isolation artifacts (6-7) and a known sesquiterpenoid (8) were isolated from the marine sponge Ircinia sp. Their chemical structures were elucidated via analyses of spectroscopic data, which included NMR and HRMS data. Two terpenoids, 1 and 4, showed PPAR delta agonistic activities, with EC50 values of 18 and 30 mu g/mL, respectively. (C) 2014 Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/31253http://dx.doi.org/10.1016/j.tetlet.2014.07.019
ISSN
0040-4039
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE