The clinical features and treatment modality of esophageal neuroendocrine tumors: a multicenter study in Korea

Title
The clinical features and treatment modality of esophageal neuroendocrine tumors: a multicenter study in Korea
Author(s)
장병익임윤정[임윤정]이창근[이창근]박선자[박선자]최석렬[최석렬]김재광[김재광]김영태[김영태]조주영[조주영]양창훈[양창훈]전훈재[전훈재]
Keywords
SMALL-CELL-CARCINOMA; GASTROINTESTINAL SYMPTOMS; OBESITY; PROGNOSIS; TRACT; SURVIVAL
Issue Date
201408
Publisher
BIOMED CENTRAL LTD
Citation
BMC CANCER, v.14
Abstract
Background: Neuroendocrine tumors (NETs) of the esophagus are extremely rare, and few cases have been reported worldwide. Thus, a comprehensive nationwide study is needed to understand the characteristics of and treatment strategy for esophageal NETs. Methods: We collected data on esophageal NET patients from 25 hospitals in Korea from 2002-2012. The incidence, location, clinical symptoms, histopathology, treatment response, and the biochemical, radiologic and endoscopic characteristics of esophageal NETs were surveyed. Results: Among 2,037 NETs arising in different gastrointestinal sites, esophageal NETs were found in 26 cases (1.3%). The mean patient age was 60.12 +/- 9.30 years with a 4:1 male predominance. In endoscopic findings, 76.9% (20/26) of NETs were located in the lower third of the esophagus and the mean size was 2.34 +/- 1.63 cm. At diagnosis, more than half the patients (15/26, 57.7%) had regional lymph node metastasis or widespread metastasis. Endoscopic resection was conducted in three cases, and in all three of them, lymph node metastasis was not found and tumor size was below 1.0 cm. All tumors were completely removable through endoscopic procedures and there was no recurrence during the follow-up period. Eighteen other patients received an operation, chemotherapy or both. Among them, nine patients (50.0%) expired because of the progression of their cancer or post-operative complications. In Kaplan-Meier survival analysis, only tumor size (more than 2.0 cm) showed prognostic significance (P = 0.045). Conclusions: Despite the general assumption that gastrointestinal NETs are benign and slow-growing tumors, the prognosis of advanced esophageal NETs is not favorable.
URI
http://hdl.handle.net/YU.REPOSITORY/31159http://dx.doi.org/10.1186/1471-2407-14-569
ISSN
1471-2407
Appears in Collections:
의과대학 > 내과학교실 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE