Enantioseparation of basic chiral compounds on a clindamycin phosphate-silica/zirconia hybrid monolith by capillary electrochromatography

Title
Enantioseparation of basic chiral compounds on a clindamycin phosphate-silica/zirconia hybrid monolith by capillary electrochromatography
Author(s)
박정학트란녹레수치딕시
Keywords
MODIFIED ZIRCONIA MONOLITH; CYCLODEXTRIN DERIVATIVES; BETA-CYCLODEXTRIN; STATIONARY-PHASE; SEPARATION; ELECTROPHORESIS; PARAMETERS; SELECTOR; CHROMATOGRAPHY; ENANTIOMERS
Issue Date
201408
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CHROMATOGRAPHY A, v.1356, pp.289 - 293
Abstract
An organic-inorganic silica/zirconia hybrid monolithic capillary column was prepared by sol-gel process in a fused-silica capillary by using triethoxysilylpropylcarbamate (TEOSPC) derivative of clindamycin phosphate (CLIP) as a chiral selector. A sol solution consisting of 6 x 10(-3) M of polyethylene glycol, 1 M of water, 2 M of acetic acid and 0.04/0.96 ratio of CLIP-TEOSPC/Zr-Bu resulted in homogeneous monolith having well defined through-pores and tightly anchored to the capillary wall. The column was employed for capillary electrochromatographic enantioseparation of eight basic chiral drugs in mobile phases consisting of acetonitrile, methanol and ammonium acetate (AA, as the electrolyte). Effects of the compositions of solvents and electrolyte in the mobile phase, applied voltage and capillary temperature on chiral separation were investigated. The highest resolution values were obtained with mobile phases consisting of 40/60 MeOH/ACN and 100 mM AA (for citalopram, Troger's base, indapamide, metoprolol, cetirizine and atropine) and 35165 MeOH/ACN and 100 mM M (for sertraline and propranolol) using -10 W applied voltage at 25 degrees C. (C) 2014 Elsevier B.V. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/31152http://dx.doi.org/10.1016/j.chroma.2014.06.089
ISSN
0021-9673
Appears in Collections:
이과대학 > 화학생화학부 > Articles
문과대학 > 중국언어문화학과 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE