Ubiquitin specific protease 2 acts as a key modulator for the regulation of cell cycle by adiponectin and leptin in cancer cells

Title
Ubiquitin specific protease 2 acts as a key modulator for the regulation of cell cycle by adiponectin and leptin in cancer cells
Author(s)
박필훈사로즈네팔쉬레스타아눕
Keywords
PROSTATE-CANCER; DEUBIQUITINATING ENZYMES; DOWN-REGULATION; D1 DEGRADATION; TUMOR GROWTH; NUDE-MICE; PATHWAY; KINASE; SUPPRESSION; APOPTOSIS
Issue Date
201509
Publisher
ELSEVIER IRELAND LTD
Citation
MOLECULAR AND CELLULAR ENDOCRINOLOGY, v.412, no.C, pp.44 - 55
Abstract
Adiponectin and leptin, both produced from adipose tissue, cause cell cycle arrest and progression, respectively in cancer cells. Ubiquitin specific protease-2 (USP-2), a deubiquitinating enzyme, is known to impair proteasome-induced degradation of cyclin D1, a critical cell cycle regulator. Herein, we investigated the effects of these adipokines on USP-2 expression and its potential role in the modulation of cell cycle. Treatment with globular adiponectin (gAcrp) decreased, whereas leptin increased USP-2 expression both in human hepatoma and breast cancer cells. In addition, overexpression or gene silencing of USP-2 affected cyclin D1 expression and cell cycle progression/arrest by adipokines. Adiponectin and leptin also modulated in vitro proteasomal activity, which was partially dependent on USP-2 expression. Taken together, our results reveal that modulation of USP-2 expression plays a crucial role in cell cycle regulation by adipokines. Thus, USP-2 would be a promising therapeutic target for the modulation of cancer cell growth by adipokines. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/31071http://dx.doi.org/10.1016/j.mce.2015.05.029
ISSN
0303-7207
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약학대학 > 약학부 > Articles
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