Survival and maintenance of regulatory T cells require the kinase TAK1

Title
Survival and maintenance of regulatory T cells require the kinase TAK1
Author(s)
장재훈Hu, Hongbo[Hu, Hongbo]Sun, Shao-Cong[Sun, Shao-Cong]
Keywords
NF-KAPPA-B; UBIQUITIN-CONJUGATING ENZYME; DIFFERENTIAL REQUIREMENT; IMMUNE-RESPONSES; ACTIVATION; UBC13; MECHANISMS; CARMA1; SUPPRESSION; TOLERANCE
Issue Date
201509
Publisher
CHIN SOCIETY IMMUNOLOGY
Citation
CELLULAR & MOLECULAR IMMUNOLOGY, v.12, no.5, pp.572 - 579
Abstract
Regulatory T (Treg) cells play a central role in regulating peripheral immune tolerance and preventing autoimmunity. Despite the extensive studies on the development of Treg cells, the molecular mechanisms that maintain the population of committed Treg cells remain poorly understood. We show here that Treg-conditional ablation of the kinase TAK1 reduced the number of Treg cells in the peripheral lymphoid organs, causing abnormal activation of conventional T cells and autoimmune symptoms. Using an inducible gene knockout approach, we further demonstrate that TAK1 is crucial for the survival of Treg cells. Expression of a constitutively active IkB kinase partially restored the level of Treg cells in the TAK1Treg-KO mice. These results suggest a crucial role for TAK1 for maintaining the survival of committed Treg cells under physiological conditions.
URI
http://hdl.handle.net/YU.REPOSITORY/31064http://dx.doi.org/10.1038/cmi.2015.27
ISSN
1672-7681
Appears in Collections:
약학대학 > 약학부 > Articles
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