BIOCHEMICAL AND IMMUNOLOGICAL PARAMETERS AS INDICATORS OF OSTEOARTHRITIS SUBJECTS: ROLE OF OH-COLLAGEN IN AUTO-ANTIBODIES GENERATION

Title
BIOCHEMICAL AND IMMUNOLOGICAL PARAMETERS AS INDICATORS OF OSTEOARTHRITIS SUBJECTS: ROLE OF OH-COLLAGEN IN AUTO-ANTIBODIES GENERATION
Author(s)
최인호모하메드아쉬라프Quazi S. Haque[Quazi S. Haque]Shams Tabrez[Shams Tabrez]Saheem Ahmad[Saheem Ahmad]
Keywords
HUMAN DNA; PHYSICOCHEMICAL ANALYSIS; GLYCATION; IMMUNOGENICITY; RECOGNITION; ANTIBODIES; PRODUCTS; DAMAGE; ALPHA
Issue Date
201509
Publisher
EXCLI JOURNAL MANAGING OFFICE
Citation
EXCLI JOURNAL, v.14, pp.1057 - 1066
Abstract
Osteoarthritis (OA) is characterized by inflammation of the knee joint, which is caused by accumulation of cytokines and C-reactive protein (CRP) in the extracellular matrix as an early immune response to infection. The articular cartilage destruction is discernible by elevated tumour necrosis factor-alpha (TNF-alpha). In this study, blood samples of knee osteoarthritis patients were analyzed for biochemical and physiological parameters based on the lipid profile, uric acid, total leukocyte count (TLC), hemoglobin percentage (Hb%) and absolute lymphocyte count (ALC). Furthermore, immunological parameters including TNF-alpha, interleukin-6 (IL-6) and CRP were analyzed. The presence of antibodies against hydroxyl radical modified collagen-II ((OH)-O-center dot-collagen-II) was also investigated in arthritis patients using direct binding ELISA. The uric acid and lipid profiles changed extensively. Specifically, increased uric acid levels were associated with OA in both genders, as were enhanced immunological parameters. The TNF-alpha level also increased in both genders suffering from OA. Finally, auto-antibodies against OH-collagen II antigen were found in the sera of arthritis patients. These results indicated that immunological parameters are better predictors or indexes for diagnosis of OA than biochemical parameters.
URI
http://hdl.handle.net/YU.REPOSITORY/30994
ISSN
1611-2156
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