Relation between cognition and neural connection from injured cingulum to brainstem cholinergic nuclei in chronic patients with traumatic brain injury

Title
Relation between cognition and neural connection from injured cingulum to brainstem cholinergic nuclei in chronic patients with traumatic brain injury
Author(s)
장성호유진선김오룡김성호김민수
Keywords
DIFFUSION TENSOR TRACTOGRAPHY; AXONAL INJURY; ANTERIOR; SYSTEM; BUNDLE; FORNIX; CORTEX
Issue Date
201409
Publisher
INFORMA HEALTHCARE
Citation
BRAIN INJURY, v.28, no.10, pp.1257 - 1261
Abstract
Background: This study investigated the relation between cognition and the neural connection from injured cingulum to brainstem cholinergic nuclei in patients with traumatic brain injury (TBI), using diffusion tensor tractography (DTT). Methods: Among 353 patients with TBI, 20 chronic patients who showed discontinuation of both anterior cingulums from the basal forebrain on DTT were recruited for this study. The Wechsler Intelligence Scale and the Memory Assessment Scale (MAS; short-term, verbal, visual and total memory) were used for assessment of cognition. Patients were divided into two groups according to the presence of a neural connection between injured cingulum and brainstem cholinergic nuclei. Results: Eight patients who had a neural connection between injured cingulum and brainstem cholinergic nuclei showed better short-term memory on MAS than 12 patients who did not (p<0.05). However, other results of neuropsychological testing showed no significant difference (p>0.05). Conclusions: Better short-term memory in patients who had the neural connection between injured cingulum and brainstem cholinergic nuclei appears to have been attributed to the presence of cholinergic innervation to the cerebral cortex through the neural connection instead of the injured anterior cingulum. The neural connection appears to compensate for the injured anterior cingulum in obtaining cholinergic innervation.
URI
http://hdl.handle.net/YU.REPOSITORY/30933http://dx.doi.org/10.3109/02699052.2014.901557
ISSN
0269-9052
Appears in Collections:
의과대학 > 재활의학교실 > Articles
의과대학 > 신경외과학교실 > Articles
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