Stilbenes Reduce Staphylococcus aureus Hemolysis, Biofilm Formation, and Virulence

Title
Stilbenes Reduce Staphylococcus aureus Hemolysis, Biofilm Formation, and Virulence
Author(s)
이진태이진형조무환이가연유시용[유시용]
Keywords
ESCHERICHIA-COLI O157/H7; CAENORHABDITIS-ELEGANS; RESVERATROL OLIGOMERS; PLANT-EXTRACTS; ALPHA-TOXIN; INHIBIT; DERIVATIVES; INFECTIONS; RESISTANCE; BACTERIA
Issue Date
201409
Publisher
MARY ANN LIEBERT, INC
Citation
FOODBORNE PATHOGENS AND DISEASE, v.11, no.9, pp.710 - 717
Abstract
Stilbenoids have a broad range of beneficial health effects. On the other hand, the emergence of antibiotic-resistant Staphylococcus aureus presents a worldwide problem that requires new antibiotics or nonantibiotic strategies. S. aureus produces alpha-hemolysin (a pore-forming cytotoxin) that has been implicated in the pathogenesis of sepsis and pneumonia. Furthermore, the biofilms formed by S. aureus constitute a mechanism of antimicrobial resistance. In this study, we investigated the hemolytic and antibiofilm activities of 10 stilbene-related compounds against S. aureus. trans-Stilbene and resveratrol at 10 mu g/mL were found to markedly inhibit human blood hemolysis by S. aureus, and trans-stilbene also inhibited S. aureus biofilm formation without affecting its bacterial growth. Furthermore, trans-stilbene and resveratrol attenuated S. aureus virulence in vivo in the nematode Caenorhabditis elegans, which is normally killed by S. aureus. Transcriptional analysis showed that trans-stilbene repressed the alpha-hemolysin hla gene and the intercellular adhesion locus (icaA and icaD) in S. aureus, and this finding was in line with observed reductions in virulence and biofilm formation. In addition, vitisin B, a stilbenoid tetramer, at 1 mu g/mL was observed to significantly inhibit human blood hemolysis by S. aureus.
URI
http://hdl.handle.net/YU.REPOSITORY/30912http://dx.doi.org/10.1089/fpd.2014.1758
ISSN
1535-3141
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공과대학 > 화학공학부 > Articles
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