Quercetin-3-O-beta-D-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells

Title
Quercetin-3-O-beta-D-glucuronide isolated from Polygonum aviculare inhibits cellular senescence in human primary cells
Author(s)
김재룡양효현[양효현]황보경Ming Shan Zheng[Ming Shan Zheng]조정희손종근김화영백석환최형철박소영
Keywords
HUMAN DERMAL FIBROBLASTS; SMOOTH-MUSCLE-CELLS; RED VINE LEAF; ANTIOXIDANT ACTIVITY; FLAVONOL GLYCOSIDES; GROWTH-FACTOR; LIFE-SPAN; IN-VITRO; QUERCETIN; METABOLITE
Issue Date
201409
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.37, no.9, pp.1219 - 1233
Abstract
Cellular senescence is known to contribute to tissue aging, a variety of age-related diseases, tissue regeneration, and cancer. Therefore, aging intervention might be useful for prevention of aging as well as age-related disease. In this study, we investigated compounds from Polygonum aviculare to determine if they inhibited cellular senescence in human primary cells, human dermal fibroblasts (HDFs) and human umbilical vein endothelial cells (HUVECs). Ten compounds from P. aviculare were purified and their inhibitory effects on adriamycin-induced cellular senescence were measured by observing senescence-associated beta-galactosidase (SA-beta-gal) activity and reactive oxygen species. Among them, compound 9 (quercetin-3-O-beta-d-glucuronide) showed inhibitory effects against cellular senescence in HDFs and HUVECs treated with adriamycin. Additionally, compound 9 rescued replicative senescence in HDFs and HUVECs. These data imply that compound 9 represses cellular senescence in human primary cells and might be useful for the development of dietary supplements or cosmetics that ameliorate tissue aging or aging-associated diseases.
URI
http://hdl.handle.net/YU.REPOSITORY/30906http://dx.doi.org/10.1007/s12272-014-0344-2
ISSN
0253-6269
Appears in Collections:
의과대학 > 생화학.분자생물학교실 > Articles
의과대학 > 영상의학과학교실 > Articles
약학대학 > 약학부 > Articles
의과대학 > 약리학교실 > Articles
의과대학 > 생리학교실 > Articles
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