Synthesis, Characterization, and In vitro Studies of PLGA-PEG Nanoparticles for Oral Insulin Delivery

Title
Synthesis, Characterization, and In vitro Studies of PLGA-PEG Nanoparticles for Oral Insulin Delivery
Author(s)
주상우Sara Hosseininasab[Sara Hosseininasab]Roghiyeh Pashaei-Asl[ Roghiyeh Pashaei-Asl]Amir Ahmad Khandaghi[Amir Ahmad Khandaghi]Hamid Tayef Nasrabadi[Hamid Tayef Nasrabadi]Kazem Nejati-Koshki[Kazem Nejati-Koshki]Abolfazl Akbarzadeh[Abolfazl Akbarzadeh]요네스피로즈살라리Soodabeh Davaran[Soodabeh Davaran]
Keywords
POLY(LACTIDE-CO-GLYCOLIDE) NANOSPHERES; POLY(D,L-LACTIC-CO-GLYCOLIC ACID); POLYMERIC NANOPARTICLES; MICROSPHERES; DRUG; COPOLYMERS; CARRIERS; GLYCOL); SYSTEM
Issue Date
201409
Publisher
WILEY-BLACKWELL
Citation
CHEMICAL BIOLOGY & DRUG DESIGN, v.84, no.3, pp.307 - 315
Abstract
Therapeutic proteins and peptides are corresponding to a major area of research in biotechnology companies and current pharmaceutical. Because of their natural instability, the enormous majority of these drugs require parenteral administration. Oral insulin delivery would be a highly attractive alternative process of administration, though it continues to be a mysterious target due to the enzymatic digestion of insulin and low levels of absorption from the gastrointestinal region. Hydrogel polymers can be considered as potential carriers for oral insulin delivery. In particular, a pH responsive hydrogel composed of PLGA-PEG has shown the ability to protect insulin from enzymes in the gastric environment and release in small intestines. However, this material has not shown similar potential for oral protein delivery of further model drugs. To date, the unique interaction between PLGA-PEG and insulin, as a potential drug for oral delivery, is not completely understood. The focus of this research is synthetization and characterization of hydrogels PLGA-PEG insulin nanoparticles and also pH sensitivity of insulin nanoparticles was investigated.
URI
http://hdl.handle.net/YU.REPOSITORY/30841http://dx.doi.org/10.1111/cbdd.12318
ISSN
1747-0277
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공과대학 > 기계공학부 > Articles
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