Polysaccharides as Nanocarriers for Therapeutic Applications

Title
Polysaccharides as Nanocarriers for Therapeutic Applications
Author(s)
딥티싱한성수신은주[신은주]
Keywords
DRUG-DELIVERY SYSTEMS; CARBOHYDRATE-CARRYING POLYMERS; GLYCOL CHITOSAN NANOPARTICLES; DEXTRAN SULFATE NANOPARTICLES; NONVIRAL GENE DELIVERY; POLYAMIDOAMINE DENDRIMER; TARGETED DELIVERY; BLOCK-COPOLYMER; POLYELECTROLYTE COMPLEXES; BIOMEDICAL APPLICATIONS
Issue Date
201409
Publisher
AMER SCIENTIFIC PUBLISHERS
Citation
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v.10, no.9, pp.2149 - 2172
Abstract
Nanocarriers have shown tremendous potential for the target-specific delivery of proteins, genes and drugs. Nanoparticles are fabricated using different natural and synthetic polymers. Natural polysaccharides are often used as building block for developing nano-sized drug delivery vehicles. The physicochemical properties of these materials, such as excellent biocompatibility, low cytotoxicity, surface charges that interact with DNA, protein and RNA, and cost effectiveness, make them exceptional base materials for nanocarrier fabrication. The mechanism for the complex formation of polysaccharides-DNA includes the electrostatic interactions between cationic polymers and anionic DNA to form polyplexes that offer unique possibilities for overcoming cellular barriers by escaping endosomal trafficking followed by cellular internalization and, consequently, enhancing the efficacy of drug and macromolecule delivery to targeted cells and tissue. Depending upon the cellular uptake and trafficking, nanocarriers are designed for different pharmacological and therapeutic applications. However, specific targeting that improves delivery remains an unsolved challenged. The process by which nanocarriers enter cells has important consequences not only for fate of these particles but also for biological systems and therapeutic applications.
URI
http://hdl.handle.net/YU.REPOSITORY/30822http://dx.doi.org/10.1166/jbn.2014.1958
ISSN
1550-7033
Appears in Collections:
중앙도서관 > rims journal
공과대학 > 화학공학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE