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dc.contributor.author박필훈ko
dc.contributor.author정길생[정길생]ko
dc.contributor.author임남경[임남경]ko
dc.contributor.author이성규[이성규]ko
dc.contributor.author이동성[이동성]ko
dc.contributor.author이인선[이인선]ko
dc.date.accessioned2015-12-17T04:00:12Z-
dc.date.available2015-12-17T04:00:12Z-
dc.date.created2015-11-13-
dc.date.issued201409-
dc.identifier.citationAMERICAN JOURNAL OF CHINESE MEDICINE, v.42, no.5, pp.1123 - 1138-
dc.identifier.issn0192-415X-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/30816-
dc.identifier.urihttp://dx.doi.org/10.1142/S0192415X14500700-
dc.description.abstractThis study was carried out to investigate the effect of Spatholobus suberectus Dunn (SS) on the protection of chondral defect and inhibition of osteoclastogenesis. To examine these effects, we measured the matrix metalloproteinase (MMP) levels in SW1353 chondrosarcoma cells and performed tartrate-resistant acid phosphatase (TRAP) staining in bone marrow macrophage (BMM)-derived osteoclasts. To investigate the anti-osteoarthritis (OA) effects, we assessed TNF-alpha-induced MMP-1, -3, -9 and tissue inhibitors of matrix metalloproteinase (TIMP) expression levels in SW1353 cells. We observed that SS extract significantly inhibited MMP and TIMP expression in SW1353 cells. Also, SS extract inhibited the receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclast differentiation. These results suggest that SS extract may have a potential in the treatment of bone loss and chondral defect by suppressing osteoclast differentiation and decreasing the expression of OA factors. Therefore, clarification of the mechanism of the action of SS extract and its active components is needed.-
dc.language영어-
dc.publisherWORLD SCIENTIFIC PUBL CO PTE LTD-
dc.subjectHUMAN CHONDROCYTES-
dc.subjectIN-VITRO-
dc.subjectOSTEOARTHRITIS-
dc.subjectCARTILAGE-
dc.subjectDIFFERENTIATION-
dc.subjectEXPRESSION-
dc.subjectCYTOKINE-
dc.subjectCOLLAGEN-
dc.subjectRECEPTOR-
dc.subjectMODEL-
dc.titleSpatholobus suberectus Inhibits Osteoclastogenesis and Stimulates Chondrogenesis-
dc.typeArticle-
dc.identifier.wosid000342562800006-
dc.identifier.scopusid2-s2.0-84926082216-
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