Spatholobus suberectus Inhibits Osteoclastogenesis and Stimulates Chondrogenesis

Title
Spatholobus suberectus Inhibits Osteoclastogenesis and Stimulates Chondrogenesis
Author(s)
박필훈정길생[정길생]임남경[임남경]이성규[이성규]이동성[이동성]이인선[이인선]
Keywords
HUMAN CHONDROCYTES; IN-VITRO; OSTEOARTHRITIS; CARTILAGE; DIFFERENTIATION; EXPRESSION; CYTOKINE; COLLAGEN; RECEPTOR; MODEL
Issue Date
201409
Publisher
WORLD SCIENTIFIC PUBL CO PTE LTD
Citation
AMERICAN JOURNAL OF CHINESE MEDICINE, v.42, no.5, pp.1123 - 1138
Abstract
This study was carried out to investigate the effect of Spatholobus suberectus Dunn (SS) on the protection of chondral defect and inhibition of osteoclastogenesis. To examine these effects, we measured the matrix metalloproteinase (MMP) levels in SW1353 chondrosarcoma cells and performed tartrate-resistant acid phosphatase (TRAP) staining in bone marrow macrophage (BMM)-derived osteoclasts. To investigate the anti-osteoarthritis (OA) effects, we assessed TNF-alpha-induced MMP-1, -3, -9 and tissue inhibitors of matrix metalloproteinase (TIMP) expression levels in SW1353 cells. We observed that SS extract significantly inhibited MMP and TIMP expression in SW1353 cells. Also, SS extract inhibited the receptor activator of nuclear factor-kappa B ligand (RANKL)-induced osteoclast differentiation. These results suggest that SS extract may have a potential in the treatment of bone loss and chondral defect by suppressing osteoclast differentiation and decreasing the expression of OA factors. Therefore, clarification of the mechanism of the action of SS extract and its active components is needed.
URI
http://hdl.handle.net/YU.REPOSITORY/30816http://dx.doi.org/10.1142/S0192415X14500700
ISSN
0192-415X
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE