Observational study to evaluate the clinical benefit of lamotrigine add-on therapy in bipolar patients in a naturalistic treatment setting

Title
Observational study to evaluate the clinical benefit of lamotrigine add-on therapy in bipolar patients in a naturalistic treatment setting
Author(s)
구본훈우영섭[우영섭]박원명[박원명]배치운[배치운]정종현[정종현]전덕인[전덕인]이정구[이정구]김문두[김문두]
Keywords
WEEKLY SYMPTOMATIC STATUS; I-DISORDER; SUBSYNDROMAL SYMPTOMS; DOUBLE-BLIND; TREATMENT OPTIONS; FOLLOW-UP; DEPRESSION; TRIALS; MOOD; MAINTENANCE
Issue Date
201409
Publisher
WILEY-BLACKWELL
Citation
ASIA-PACIFIC PSYCHIATRY, v.6, no.3, pp.334 - 341
Abstract
IntroductionThe objective of the current study was to assess, in a naturalistic treatment setting, the clinical benefits of lamotrigine add-on therapy for patients with bipolar disorder. MethodsThis was an open-label, prospective, naturalistic, 12-week, observational study that included 98 bipolar patients treated with lamotrigine add-on therapy, in addition to mood stabilizers or atypical antipsychotics for 1-4 weeks. The clinical benefits of lamotrigine augmentation were evaluated using the Clinical Global Impression-Clinical Benefit (CGI-CB) Scale, and the Clinical Global Impression of Bipolar Disorder-Severity scale was used to evaluate the severity of the patients' conditions. ResultsAccording to paired t-test analyses, the mean CGI-CB score significantly decreased from 7.22.7 at baseline to 3.8 +/- 2.5 at Week 12. Likewise, the mean score for Clinical Global Impression of Bipolar Disorder-Severity scale significantly decreased from 4.7 +/- 0.9 at baseline to 3.1 +/- 1.2 at Week 12. Analysis of covariance showed that the extent to which CGI-CB scores changed from baseline to Week 12 did not significantly differ between patients with bipolar I and II disorder. However, the change in CGI-CB scores between Weeks 4 and 12 was significantly smaller in bipolar II patients than bipolar I patients. A total of 21 (21.4%) patients dropped out during the course of the study, and 30 patients (30.6%) reported 82 adverse events. DiscussionThe results of this study demonstrated that the use of lamotrigine in patients with bipolar disorder, especially those whom conventional mood stabilizers or antipsychotics are insufficiently effective or intolerable, can be beneficial regardless of the type of bipolar disorder.
URI
http://hdl.handle.net/YU.REPOSITORY/30806http://dx.doi.org/10.1111/appy.12095
ISSN
1758-5864
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의과대학 > 정신건강의학교실 > Articles
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