Treatment and Survival of Patients With Occult Breast Cancer With Axillary Lymph Node Metastasis: A Nationwide Retrospective Study

Title
Treatment and Survival of Patients With Occult Breast Cancer With Axillary Lymph Node Metastasis: A Nationwide Retrospective Study
Author(s)
이수정손귀연[손귀연]손병호[손병호]강은영[강은영]정성호[정성호]조세호[조세호]백성희[백성희]이유라[이유라]김희정[김희정]고범석[고범석]유정한[유정한]이정원[이정원]안세현[안세현]
Keywords
IPSILATERAL BREAST; CARCINOMA; LYMPHADENOPATHY; EXPERIENCE; MANAGEMENT; ADENOPATHY; OUTCOMES; ORIGIN
Issue Date
201409
Publisher
WILEY-BLACKWELL
Citation
JOURNAL OF SURGICAL ONCOLOGY, v.110, no.3, pp.270 - 274
Abstract
Background and ObjectivesOccult breast cancer (OBC) accounts for 0.3-1.0% of all breast cancers and is a rare presentation of the disease. The present retrospective study examined the overall survival and prognostic factors associated with OBC in Korea. MethodThe study included 142 OBC patients identified from the Korean Breast Cancer Society cancer registry from January 1990 to December2009. All patients had pathologically positive axillary lymph nodes (N1-N3) and pathologically and radiologically negative in-breast lesions (T0/Tx) based on a retrospective review of the database. ResultsNo statistically significant differences in overall survival were observed between patients undergoing axillary lymph node dissection (ALND) only (80.8%), breast conserving surgery (BCS) with ALND (98.0%), and mastectomy with ALND (92.5%) with P-value of 0.061. Nodal status was a significant prognostic factor (P=0.004) on univariate analysis. When compared with T1 patients group, T0/TxN1 patients showed better survival than T1N1 patients (hazard ratio [HR] 0.253; 95% confidence interval, 0.104-0.618; P=0.003), but T0/TxN2, T0/TxN3 patients showed similar survival to T1N2, T1N3 patients. ConclusionsOBC patients treated with ALND only showed comparable outcomes to those undergoing ALND combined with BCS or mastectomy. Nodal status may be an independent predictor of poor outcome in OBC patients. J. Surg. Oncol. 2014 110:270-274. (c) 2014 Wiley Periodicals, Inc.
URI
http://hdl.handle.net/YU.REPOSITORY/30796http://dx.doi.org/10.1002/jso.23644
ISSN
0022-4790
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의과대학 > 성형외과학교실 > Articles
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