The effect of metal-doped TiO2 nanoparticles on zebrafish embryogenesis

Title
The effect of metal-doped TiO2 nanoparticles on zebrafish embryogenesis
Author(s)
강미숙박형근[박형근]김정인[김정인]여민경[여민경]
Keywords
HYDROGEN-PRODUCTION; OXIDATIVE STRESS; VISIBLE-LIGHT; TOXICITY; DEGRADATION; PHOTOCATALYST; PERFORMANCE; MECHANISM; EXPOSURE; CELLS
Issue Date
201409
Publisher
KOREAN SOCIETY TOXICOGENOMICS & TOXICOPROTEOMICS-KSTT
Citation
MOLECULAR & CELLULAR TOXICOLOGY, v.10, no.3, pp.293 - 301
Abstract
In this study, we manufactured metal-doped TiO2 nanoparticles using several transition metals (Mn, Fe, Ni, and Cu). Their physicochemical properties were evaluated by transmission electron microscopy (TEM), X-ray diffiaction (XRD) analysis, and UV-visible spectra. The energy efficiency of the metals increased in the order of Ni- < Cu- < Mn- < Fe-TiO2. For toxicity testing, zebrafish embryos were exposed to 4 mg L-1 of metal-doped TiO2 nanoparticles. We determined the survival rate (%) and abnormal morphology rate (%) of the exposed embryos and also observed apoptosis and necrosis using confocal microscopy. The metal TiO2 nanoparticles showed acute toxicity in the order of Mn- < Cu- < Ni- <= Fe-TiO2. Although the Fe-TiO2 NPs group demonstrated the highest photocatalytic performance, it also exhibited the highest toxic effects. Among the metals, the Mn-TiO2 NPs group demonstrated improved photocatalysis compared to the other samples except for the Fe-TiO2 NPs along with the lowest toxic effects. For these reasons, the most suitable doping metal was the Mn-TiO2 NPs group considering its energy activity and environmental impacts.
URI
http://hdl.handle.net/YU.REPOSITORY/30791http://dx.doi.org/10.1007/s13273-014-0033-8
ISSN
1738-642X
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이과대학 > 화학생화학부 > Articles
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