Ethylacetate extracts of the muscles of Anguilla japonica suppress glucose levels in db/db mice via activation of AMP-activated protein kinase

Title
Ethylacetate extracts of the muscles of Anguilla japonica suppress glucose levels in db/db mice via activation of AMP-activated protein kinase
Author(s)
장현욱정용태양주혜이선김금진김동수[김동수]김철호[김철호]나민균[나민균]
Keywords
FATTY-ACID OXIDATION; METABOLIC SYNDROME; SKELETAL-MUSCLE; TRANSPORT; MECHANISMS; RESISTANCE; INSULIN; CELLS
Issue Date
201410
Publisher
KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
Citation
FOOD SCIENCE AND BIOTECHNOLOGY, v.23, no.5, pp.1695 - 1701
Abstract
Hypoglycemic effects of ethylacetate extracts of Anguilla japonica (EMA) muscles in db/db mice were investigated. To understand the mechanism responsible for the hypoglycemic effects of EMA, the effects of EMA on AMP-activated protein kinase (AMPK) activation in L6 myotubes and in vivo using type II diabetic db/db mice were analyzed. In L6 myotubes, the phosphorylation degrees of AMPK and acetyl-CoA carboxylase (ACC) were markedly increased and glucose uptake was significantly (p < 0.001) increased by EMA, compared with untretaed L6 myotubes. However, in L6 myotubes, these effects were abolished by compound C, an AMPK inhibitor. Moreover, EMA significantly reduced non-fasting blood glucose and serum insulin levels, and strongly induced AMPK phosphorylation in skeletal muscle tissues of db/db mice. EMA regulates glucose levels in L6 myotubes and in diabetic mice by activation of AMPK. Beneficial effects for diabetes treatment are indicated.
URI
http://hdl.handle.net/YU.REPOSITORY/30686http://dx.doi.org/10.1007/s10068-014-0231-0
ISSN
1226-7708
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약학대학 > 약학부 > Articles
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