TBX21 participates in innate immune response by regulating Toll-like receptor 2 expression in Streptococcus pneumoniae infections

Title
TBX21 participates in innate immune response by regulating Toll-like receptor 2 expression in Streptococcus pneumoniae infections
Author(s)
우창훈신슬기[신슬기]고서현[고서현]임재향[임재향]
Keywords
NONTYPABLE HAEMOPHILUS-INFLUENZAE; FACTOR T-BET; TRANSCRIPTION FACTOR; STEROID-HORMONES; EPITHELIAL-CELLS; DENDRITIC CELLS; MUC5AC MUCIN; PNEUMOLYSIN; COLONIZATION; VIRUS
Issue Date
201410
Publisher
WILEY-BLACKWELL
Citation
MOLECULAR ORAL MICROBIOLOGY, v.29, no.5, pp.233 - 243
Abstract
Nasopharyngeal carriage of Streptococcus pneumoniae (pneumococcus) plays an important role in the development of invasive diseases, and is also critically involved in setting up respiratory bacterial and viral infections. We previously reported that pneumococcus, one of the commonly carried bacteria in the nasopharynx, regulates non-typeable Haemophilus influenzae-induced inflammation by upregulating the expression of Toll-like receptor 2 (TLR2). However, the underlying molecular mechanisms by which TLR2 expression is regulated during pneumococcal infections have not yet been well characterized. TBX21 is an important transcription factor of adaptive immunity, but there is an increasing body of evidence pointing to a role in regulating innate immunity. The expression of TBX21 was reported in epithelial cells, but the expression and role of TBX21 in respiratory epithelium, especially for regulating TLR2, has not yet been studied. In this study, we found that pneumococcus upregulates TBX21 expression in the respiratory epithelium. The effect of pneumococcus on TBX21 expression was dependent on its cytoplasmic toxin, pneumolysin. In addition, epithelial TBX21 expression was not regulated by the gram-negative bacterium non-typeable Haemophilus influenzae, peptidoglycan or endotoxin. Deficiency of TBX21 in mice or knocking down TBX21 in epithelial cells suppressed pneumococcus-induced TLR2 expression, but not that of TLR4 or TLR9. These results indicate that the adaptive immune regulator TBX21 participates in regulating innate immune responses, through regulation of TLR2 expression during pneumococcal infections.
URI
http://hdl.handle.net/YU.REPOSITORY/30684http://dx.doi.org/10.1111/omi.12061
ISSN
2041-1006
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의과대학 > 약리학교실 > Articles
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