Nano-Biomimetics for Nano/Micro Tissue Regeneration

Title
Nano-Biomimetics for Nano/Micro Tissue Regeneration
Author(s)
한성수딥티싱돌리싱조선미
Keywords
PEPTIDE NANOFIBER SCAFFOLDS; ENHANCED RAMAN-SPECTROSCOPY; FUNCTIONALIZED CARBON NANOTUBES; UV-NANOIMPRINT LITHOGRAPHY; SELF-ASSEMBLED MONOLAYERS; RESONANCE ENERGY-TRANSFER; SMOOTH-MUSCLE-CELLS; NERVE REGENERATION; DRUG-DELIVERY; QUANTUM DOTS
Issue Date
201410
Publisher
AMER SCIENTIFIC PUBLISHERS
Citation
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, v.10, no.10, pp.3141 - 3161
Abstract
Nanostructured biomimetics have recently shown great promise in the field of tissue engineering. They can be used as nanoscaffolds and tailored at the molecular level. The scaffold topography closely resembles the native extracellular matrix in terms of framing, porosity and bio-functionality. This review covers the approaches used for biomimetic fabrication, including soft lithography, the plasmonic nanohybrid matrix method and multilayer self-assembly scaffolds for tissue regeneration. It brings together knowledge from different arenas about the synthesis, characterization and functionalization of matrices to accelerate the tissue regeneration process. Every tissue in the body presents different challenges and requires a specific fabrication process designed to identify and mirror the particular organ. For example, microfluidics systems aim to mimic the extracellular matrix of vascular and cartilage tissue, and these systems have different parts with completely different mechanical strength, cellular adhesion and interplay between matrix and cells. A fully functional nanomatrix designed by a self-assembling methodology for use as a vascular tissue engineering scaffold needs to have intrinsic microvessels that facilitate the transportation of metabolites and nutrients. Similarly, in the case of peripheral nerve regeneration, a scaffold needs to have sufficient mechanical strength to protect the regenerating tissue, yet be biodegradable enough to avoid a possible second surgery. To enhance the functionality of scaffolds, increasing focus has been placed on in vitro and in vivo research to achieve optimal scaffold design. Nanobiomimetics unarguably offer the most suitable physicochemical scaffold properties for tissue regeneration.
URI
http://hdl.handle.net/YU.REPOSITORY/30671http://dx.doi.org/10.1166/jbn.2014.1941
ISSN
1550-7033
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공과대학 > 화학공학부 > Articles
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