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dc.contributor.author김종오ko
dc.contributor.author티르거네쉬라마사미ko
dc.contributor.author김정환ko
dc.contributor.author최주연ko
dc.contributor.author트란탄힙ko
dc.contributor.author최한곤[최한곤]ko
dc.contributor.author용철순ko
dc.date.accessioned2015-12-17T03:56:43Z-
dc.date.available2015-12-17T03:56:43Z-
dc.date.created2015-11-13-
dc.date.issued201410-
dc.identifier.citationJOURNAL OF MATERIALS CHEMISTRY B, v.2, no.37, pp.6324 - 6333-
dc.identifier.issn2050-750X-
dc.identifier.urihttp://hdl.handle.net/YU.REPOSITORY/30669-
dc.identifier.urihttp://dx.doi.org/10.1039/c4tb00867g-
dc.description.abstractThe co-encapsulation of two or more drugs in the same carrier affords synergistic therapeutic effects and enhanced therapeutic potency. For this, polyethylene oxide-b-polyacrylic acid di-block polymer based-smart pH-sensitive di-block polyelectrolyte complex (PEC) micelles were designed to encapsulate mitoxantrone (MTX) and doxorubicin (DOX) with high payload capacity and precise drug ratio. Three molar ratios (MTX/DOX: 2 : 1, 1 : 1, 1 : 2) of the drug-loaded PECs were prepared with high payload capacity and evaluated for various physicochemical characteristics. The dual drug combination exhibited a synergistic cytotoxic activity against both sensitive (MCF-7 and A-549) and resistant cancer cell lines (MDA-MB-231), unlike the individual drugs. Dual drug-loaded nanosystems (MTX/DOX-M) prolonged the blood circulation of drugs, and a synergic ratio was maintained throughout the study period. MTX/DOX-M exhibited superior therapeutic efficacy in xenograft models; by contrast, the free drug cocktail caused a significant loss of body weight in mice. Taken together, our results suggest that PEC micelles have great potential as nano-scaled therapeutic delivery systems for combination chemotherapy.-
dc.language영어-
dc.publisherROYAL SOC CHEMISTRY-
dc.subjectBLOCK IONOMER COMPLEXES-
dc.subjectDRUG-
dc.subjectDELIVERY-
dc.subjectNANOPARTICLES-
dc.subjectTHERAPY-
dc.subjectCANCER-
dc.subjectPHARMACOKINETICS-
dc.subjectDOXORUBICIN-
dc.subjectANTICANCER-
dc.subjectPACLITAXEL-
dc.titlepH sensitive polyelectrolyte complex micelles for highly effective combination chemotherapy-
dc.typeArticle-
dc.identifier.wosid000341457500018-
dc.identifier.scopusid2-s2.0-84907075319-
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