Complete NMR assignments of undegraded asterosaponins from Asterias amurensis

Title
Complete NMR assignments of undegraded asterosaponins from Asterias amurensis
Author(s)
장현욱황인현[황인현]Roshan Kulkarni[Roshan Kulkarni]양민혜[양민혜]추수진[추수진]주미이상명[이상명]장태수[장태수]정길상[정길상]나민균[나민균]
Keywords
FATTY-ACID SYNTHASE; STEROIDAL GLYCOSIDE SULFATES; STARFISH SAPONINS
Issue Date
201410
Publisher
PHARMACEUTICAL SOC KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.37, no.10, pp.1252 - 1263
Abstract
Four asterosaponins, thornasteroside A (1), versicoside A (2), anasteroside B (3), and asteronylpentaglycoside sulfate (4), were isolated from the predatory starfish Asterias amurensis Lutken. Unlike previous studies focusing on structure elucidation by degradation of the complex saponin molecules, complete nuclear magnetic resonance (NMR) assignment for the intact molecules was accomplished using 600 MHz high magnetic field NMR. The complete set of NMR assignments can help in the structure elucidation of asterosaponins isolated in low yields without resorting to chemical degradation. Furthermore, this approach can be extended to other complex steroidal saponins, which may accelerate the discovery of bioactive secondary metabolites from this invasive starfish species.
URI
http://hdl.handle.net/YU.REPOSITORY/30637http://dx.doi.org/10.1007/s12272-014-0374-9
ISSN
0253-6269
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약학대학 > 약학부 > Articles
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