Synthesis of Novel 4H-Chromenes Containing a Pyrimidine-2-Thione Function in the Presence of Fe3O4 Magnetic Nanoparticles and Study of Their Antioxidant Activity

Title
Synthesis of Novel 4H-Chromenes Containing a Pyrimidine-2-Thione Function in the Presence of Fe3O4 Magnetic Nanoparticles and Study of Their Antioxidant Activity
Author(s)
주상우Mehdi Khoobi[Mehdi Khoobi]알리라마자니Zahra Hojjati[Zahra Hojjati]Raheleh Shakeri[Raheleh Shakeri]Mehdi Khoshneviszadeh[Mehdi Khoshneviszadeh]Susan Kaboudanian Ardestani[Susan Kaboudanian Ardestani]Abbas Shafiee[Abbas Shafiee]Alireza Foroumadi[Alireza Foroumadi]
Keywords
SOLVENT-FREE CONDITIONS; ONE-POT SYNTHESIS; SUBSTITUTED 1,3,4-OXADIAZOLE DERIVATIVES; AROMATIC CARBOXYLIC-ACIDS; N-ISOCYANIMINOTRIPHENYLPHOSPHORANE; DIALKYL ACETYLENEDICARBOXYLATES; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; 4-COMPONENT SYNTHESIS; COORDINATION POLYMER
Issue Date
201410
Publisher
TAYLOR & FRANCIS LTD
Citation
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS, v.189, no.10, pp.1586 - 1595
Abstract
The aim of the present work was to search for identification of novel reactive oxygen species (ROS) scavengers by testing new fused chromenopyrimidinethiones, which was synthesized using Fe3O4 nanoparticles. The new compounds were also tested for their cytotoxic activity. The obtained results showed that the incorporated pyrimidinethione moiety significantly increase antioxidant activity. In conclusion, the study of the pharmacological properties of the new chromenopyrimidinethiones allowed establishing new structure-activity relationships for splitting antioxidant and cytotoxic activity of these compounds.
URI
http://hdl.handle.net/YU.REPOSITORY/30635http://dx.doi.org/10.1080/10426507.2014.884094
ISSN
1042-6507
Appears in Collections:
공과대학 > 기계공학부 > Articles
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