FPDHP, a novel anticancer agent, induces cell detachment and caspase-dependent apoptosis in Caki cells

Title
FPDHP, a novel anticancer agent, induces cell detachment and caspase-dependent apoptosis in Caki cells
Author(s)
이응석박전수[박전수]김완태[김완태]김신[김신]권택규[권택규]장병철[장병철]박종욱[박종욱]
Keywords
II INHIBITORY-ACTIVITY; TOPOISOMERASE-I; DNA-TOPOISOMERASES; THERAPEUTIC TARGET; CANCER-THERAPY; CYTOTOXICITY; DEATH; NECROPTOSIS; AUTOPHAGY; PROTEIN
Issue Date
201410
Publisher
SPANDIDOS PUBL LTD
Citation
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, v.34, no.4, pp.1051 - 1056
Abstract
The inhibition of topoisomerase can suppress the growth of cancer cells and induce apoptosis. The aim of this study was to evaluate the anticancer effects and mechanisms of action of a novel topoisomerase inhibitor, 4-(furan-2-yl)-2-(pyridin-2-yl)-5,6-dihydro-1,10-phenanthroline (FPDHP). FPDHP suppressed the growth of Caki, A549, HT29 and MDA-MB-231 cells, and induced caspase-dependent apoptosis in the Caki cells. In particular, FPDHP also induced caspase-dependent apoptosis and the downregulation of the protein expression levels of cellular FLICE-like inhibitory protein (cFLIP) and the phosphorylation of Akt in Caki cells. Notably, the overexpression of cFLIP, but not that of Akt, in part, blocked the FPDHP-mediated apoptosis in Caki cells. In addition, FPDHP was further shown to induce the caspase-independent detachment of Caki cells from the culture dish; higher populations of apoptotic cells were observed in the detached cells than in the attached cells. To the best of our knoweledge, these results collectively demonstrate for the first time that FPDHP has a killing effect on Caki cells, which is mediated through both caspase-dependent apoptosis and caspase-independent cell detachment.
URI
http://hdl.handle.net/YU.REPOSITORY/30620http://dx.doi.org/10.3892/ijmm.2014.1875
ISSN
1107-3756
Appears in Collections:
약학대학 > 약학부 > Articles
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE