Hemin Improves Insulin Sensitivity in Skeletal Muscle in High Fat-Fed Mice

Title
Hemin Improves Insulin Sensitivity in Skeletal Muscle in High Fat-Fed Mice
Author(s)
박소영주태진[주태진]권우영[권우영]김종연김용운김용대이인규[이인규]
Keywords
ACTIVATED PROTEIN-KINASE; SUPEROXIDE-PRODUCTION; LIPID-METABOLISM; RESISTANCE; LIVER; OXYGENASE-1; INHIBITION; PALMITATE; TRANSPORT; MECHANISM
Issue Date
201410
Publisher
JAPANESE PHARMACOLOGICAL SOC
Citation
JOURNAL OF PHARMACOLOGICAL SCIENCES, v.126, no.2, pp.115 - 125
Abstract
The present study examined whether hemin could prevent the development of high-fat diet induced insulin resistance in the liver and skeletal muscle using a hyperinsulinemic-euglycemic clamp. A four-week high-fat feeding to mice increased the body weight, fat mass, and plasma levels of insulin and lipid, which were reduced by hemin. High-fat diet reduced whole body glucose uptake, which were increased by hemin. Insulin-stimulated hepatic glucose production (HGP) was increased by high-fat diet, but hemin had no significant effect on HGP. Skeletal muscle glucose uptake was reduced by high-fat diet, and hemin normalized the glucose uptake. High-fat diet increased triglyceride levels and mRNA levels of lipogenic enzymes, and decreased mRNA levels of enzymes involved in lipid beta-oxidation, which was reversed by hemin. Phosphorylated AMP-activated protein kinase levels were increased in the skeletal muscle of high fat fed hemin-injected mice. High-fat diet reduced mRNA levels of antioxidant enzymes and increased mRNA levels of inflammatory cytokines and nitrotyrosine levels, which was normalized by hemin in the skeletal muscle. However, hemin had no significant effect on these factors in the liver. These results suggest that hemin prevents the development of high-fat diet induced insulin resistance by increased insulin sensitivity in the skeletal muscle.
URI
http://hdl.handle.net/YU.REPOSITORY/30615http://dx.doi.org/10.1254/jphs.14003FP
ISSN
1347-8613
Appears in Collections:
의과대학 > 생리학교실 > Articles
의과대학 > 이비인후과학교실 > Articles
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