Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings

Title
Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings
Author(s)
허지안박지웅[박지웅]함지연[함지연]김석화[김석화]서지연[서지연]김상현[김상현]이승주[이승주]민해정[민해정]최성현[최성현]최라미[최라미]김희진[김희진]오소희[오소희]최태현[최태현]Yan Lee[Yan Lee]
Keywords
FOREIGN-BODY REACTION; BREAST IMPLANTS; CELL-ADHESION; PROTEIN ADSORPTION; AUGMENTATION MAMMAPLASTY; PLASMA TREATMENT; CONTRACTURE; POLYMERS; SURFACES; TISSUE
Issue Date
201410
Publisher
ELSEVIER SCI LTD
Citation
ACTA BIOMATERIALIA, v.10, no.10, pp.4217 - 4225
Abstract
Despite their popular use in breast augmentation and reconstruction surgeries, the limited biocompatibility of silicone implants can induce severe side effects, including capsular contracture - an excessive foreign body reaction that forms a tight and hard fibrous capsule around the implant. This study examines the effects of using biomembrane-mimicking surface coatings to prevent capsular formations on silicone implants. The covalently attached biomembrane-mimicking polymer, poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), prevented nonspecific protein adsorption and fibroblast adhesion on the silicone surface. More importantly, in vivo capsule formations around PMPC-grafted silicone implants in rats were significantly thinner and exhibited lower collagen densities and more regular collagen alignments than bare silicone implants. The observed decrease in alpha-smooth muscle actin also supported the alleviation of capsular formations by the biomembrane-mimicking coating. Decreases in inflammation-related cells, myeloperoxidase and transforming growth factor-beta resulted in reduced inflammation in the capsular tissue. The biomembrane-mimicking coatings used on these silicone implants demonstrate great potential for preventing capsular contracture and developing biocompatible materials for various biomedical applications. (C) 2014 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/30594http://dx.doi.org/10.1016/j.actbio.2014.07.007
ISSN
1742-7061
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의과대학 > 내과학교실 > Articles
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