Novel Alginate-Gelatin Hybrid Nanoparticle for Drug Delivery and Tissue Engineering Applications

Title
Novel Alginate-Gelatin Hybrid Nanoparticle for Drug Delivery and Tissue Engineering Applications
Author(s)
한성수딥티싱이은미돌리싱최순모조선미박선주
Keywords
NANOCARRIERS; SYSTEMS; GROWTH; BIODISTRIBUTION; BIOSYNTHESIS; CELLS
Issue Date
201411
Publisher
HINDAWI PUBLISHING CORPORATION
Citation
JOURNAL OF NANOMATERIALS
Abstract
Novel alginate-gelatin hybrid nanoparticles were fabricated using single oil in water (O/W) emulsification techniques. Physicochemical property of the particle was characterized using scanning electron microscopy and Fourier's transmission infrared spectroscopy. Particle size was determined using zeta potential metastasize analyzer and was found to be in range of 400-600 nm. AGNPs were used for culturing human keratinocytes for two weeks to check biocompatibility of synthesized AGNPs. 3-(4,5Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay showed increased metabolic activity of cells cultured on AGNPs in comparison to two-dimensional (2D) system (control). Cellular attachment on nanoparticle was further confirmed using SEMand 4 ',6-diamidino-2-phenylindole staining. The drug release profile shows possible electrostatic bond between alginate and gelatin resulting in controlled release of drug fromAGNPs. For the first time alginate-gelatin hybrid nanosystem has been fabricated and all results showed it can be used as potential system for delivery of drug and therapeutical agents to cells and can also be used for regenerative medicine applications.
URI
http://hdl.handle.net/YU.REPOSITORY/30525http://dx.doi.org/10.1155/2014/124236
ISSN
1687-4110
Appears in Collections:
공과대학 > 화학공학부 > Articles
이과대학 > 생명과학과 > Articles
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