A randomised clinical trial of 10-day concomitant therapy and standard triple therapy for Helicobacter pylori eradication

Title
A randomised clinical trial of 10-day concomitant therapy and standard triple therapy for Helicobacter pylori eradication
Author(s)
이시형허준[허준]전성우[전성우]정진태[정진태]권중구[권중구]김은영[김은영]이동욱[이동욱]서향은[서향은]하창윤[하창윤]장병익
Keywords
QUADRUPLE THERAPY; ANTIBIOTIC-RESISTANCE; SEQUENTIAL THERAPY; CONSENSUS REPORT; INFECTION; LEVOFLOXACIN; MANAGEMENT; STRAINS; ARTICLE; REGION
Issue Date
201411
Publisher
ELSEVIER SCIENCE INC
Citation
DIGESTIVE AND LIVER DISEASE, v.46, no.11, pp.980 - 984
Abstract
Background: As a result of increased resistance to antibiotics, Helicobacter pylori eradication rates using standard triple therapy have been declining. Aim: To validate the efficacy and tolerability of a concomitant regimen as a first-line treatment for H. pylori infection. Methods: A total of 348 naive H. pylori-infected patients from six hospitals in Korea were randomly assigned to concomitant therapy and standard triple therapy groups. The concomitant regimen consisted of 30 mg of lansoprazole, 1 g of amoxicillin, 500 mg of clarithromycin, and 500 mg of metronidazole, twice daily for 10 days. The standard triple regimen consisted of 30 mg of lansoprazole, 1 g of amoxicillin, and 500 mg of clarithromycin, twice daily for 10 days. Results: Concomitant and standard eradication rates were 78.7% (137/174) vs. 70.7% (123/174) by intention-to-treat (p = 0.084) and 88.7% (133/150) vs. 78.4% (120/153) by per-protocol (p = 0.016), respectively. The two groups were similar with regard to the incidence of adverse events. Conclusions: Although 10-day concomitant therapy was validated as a suboptimal treatment option for the treatment of H. pylori infection, this regimen is expected to be a promising starting point in the development of an optimal treatment regimen for H. pylori infection. (C) 2014 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
URI
http://hdl.handle.net/YU.REPOSITORY/30521http://dx.doi.org/10.1016/j.dld.2014.07.018
ISSN
1590-8658
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의과대학 > 내과학교실 > Articles
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